Search results for "physical environment"
showing 10 items of 17 documents
Senior Housing as a Living Environment That Supports Well-Being in Old Age
2020
Background: In different parts of the world new models of senior housing have rapidly appeared, which indicates that existing housing and care models are not fulfilling the hopes and needs of current and new generations of older people. Material and Methods: This qualitative study focuses on one type of communal senior housing complex located in a mid-sized town in Central Finland. The complex was designed to have accessible low-maintenance apartments and common spaces, and to be near easily accessible green spaces, amenities, services, and public transport. The complex has a part-time community coordinator. The minimum age limit is set at 55 years. The data consists of 36 qualitative inter…
Permeability changes of integrin-containing multivesicular structures triggered by picornavirus entry.
2014
Cellular uptake of clustered α2β1-integrin induces the formation of membrane compartments that subsequently mature into a multivesicular body (MVB). Enhanced internalization mediated by clustered integrins was observed upon infection by the picornavirus echovirus 1 (EVI). We elucidated the structural features of virus-induced MVBs (vMVBs) in comparison to antibody-induced control MVBs (mock infection) by means of high-pressure cryo fixation of cells followed by immuno electron tomography during early entry of the virus. Three-dimensional tomograms revealed a marked increase in the size and complexity of these vMVBs and the intraluminal vesicles (ILVs) at 2 and 3.5 hours post infection (p.i.…
Réflexion sur le lieu de consommation culturelle. Une application au cas des musiques actuelles
2004
The following study sheds light on the importance of managing a forsaken element of cultural experience : the place. Because of the weakness of the works relating to this element in the cultural domain, we use the works in distribution. Several competing theories are considered to conceptualize the cultural place: the own characteristics of the place, the behaviors and the “responses to the place”. The last track having our preference, an exploratory study will come in support to define the differents dimensions that compose this “response to the place”. Pop music will constitute our field of application.
Different neighborhood walkability indexes for active commuting to school are necessary for urban and rural children and adolescents
2020
This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness and the European Regional Development Fund [grant no. DEP2016-75598-R, MINECO/FEDER, UE]. Additionally, this study takes place thanks to the funding from the University of Granada Plan Propio de Investigacion 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES) -and the Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades, European Regional Development Fund [grant no. SOMM17/6107/UGR]. The funding body had no role in the study design or collection, analysis, or interpretation of the data or in writing the manuscript.
Comment positionner l'offre culturelle ? De la compréhension de la relation personne – objet à l'intégration du lieu de consommation
2005
This article seeks to answer the strategic question of the cultural institutions positioning by insisting on the need, on the one hand, for analyzing the total relation between the consumer and the cultural object (central road of positioning definition) and, on the other hand, for considering the role of the cultural place (peripheral road). We will be able to consider that the ways of differentiation are multiple and correspond to a conceptualization of the ambivalent cultural experience.
Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies
2020
Introduction: To date, the evidence for an association between perfluoroalkyl substances (PFAS) exposure and attention deficit and hyperactivity disorder (ADHD) is inconclusive. Objective: We investigated the association between early life exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), and ADHD in a collaborative study including nine European population-based studies, encompassing 4,826 mother-child pairs. Methods: Concentrations of PFOS and PFOA were measured in maternal serum/plasma during pregnancy, or in breast milk, with different timing of sample collection in each cohort. We used a validated pharmacokinetic model of pregnancy and lactation to estimate…
Conceptualisation et mesure de la valeur perçue d'un lieu de consommation. Application au domaine du spectacle vivant
2005
This article seeks to understand the role of a place during a consumption experience. We explore the track of value and present a scale of perceived value of a place. In this way, we have done a state of art about the value and we justify for using this concept to grasp the physical environment. We present the stages of the scale's building.
Chromatin organization regulates viral egress dynamics.
2017
Various types of DNA viruses are known to elicit the formation of a large nuclear viral replication compartment and marginalization of the cell chromatin. We used three-dimensional soft x-ray tomography, confocal and electron microscopy, combined with numerical modelling of capsid diffusion to analyse the molecular organization of chromatin in herpes simplex virus 1 infection and its effect on the transport of progeny viral capsids to the nuclear envelope. Our data showed that the formation of the viral replication compartment at late infection resulted in the enrichment of heterochromatin in the nuclear periphery accompanied by the compaction of chromatin. Random walk modelling of herpes s…
Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells.
2022
Upon infection, viruses hijack the cell machinery and remodel host cell structures to utilize them for viral proliferation. Since viruses are about a thousand times smaller than their host cells, imaging virus-host interactions at high spatial resolution is like looking for a needle in a haystack. Scouting gross cellular changes with fluorescent microscopy is only possible for well-established viruses, where fluorescent tagging is developed. Soft X-ray tomography (SXT) offers 3D imaging of entire cells without the need for chemical fixation or labeling. Here, we use full-rotation SXT to visualize entire human B cells infected by the herpes simplex virus 1 (HSV-1). We have mapped the temporo…
What makes John move? Outdoor play physical environmental factors changing a child’s activity from sedentary to physically active: longitudinal mixed…
2021
Children’s low physical activity levels call for an investigation of what can promote activity for excessively sedentary children. The purpose of this longitudinal mixed-method case study in an early childhood education (ECE) environment was to observe one sedentary child’s free outdoor playtime in four seasons and determine the physical environmental factors changing his activity from sedentary to physically active. Systematic observation of video material and quantitative analysis were used to identify the most sedentary individual of the one ECE group. The child was named “John”. Qualitative analysis of John’s video material showed that during the four seasons he spent an average of 25% …